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4URA

Crystal structure of human JMJD2A in complex with compound 14a

Summary for 4URA
Entry DOI10.2210/pdb4ura/pdb
DescriptorLYSINE-SPECIFIC DEMETHYLASE 4A, 1,2-ETHANEDIOL, SULFATE ION, ... (7 entities in total)
Functional Keywordsoxidoreductase, jumonjic, histone demethylase
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationNucleus : O75164
Total number of polymer chains2
Total formula weight84591.95
Authors
Primary citationEngland, K.S.,Tumber, A.,Krojer, T.,Scozzafava, G.,Ng, S.S.,Daniel, M.,Szykowska, A.,Che, K.,von Delft, F.,Burgess-Brown, N.A.,Kawamura, A.,Schofield, C.J.,Brennan, P.E.
Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitor.
Medchemcomm, 5:1879-1886, 2014
Cited by
PubMed: 26682034
DOI: 10.1039/C4MD00291A
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.23 Å)
Structure validation

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