4UMX

IDH1 R132H in complex with cpd 1

Summary for 4UMX

• Entry DOI: 10.2210/pdb4umx/pdb
• Related: 4UMY
• Descriptor: ISOCITRATE DEHYDROGENASE [NADP] CYTOPLASMIC, 2,6-bis(1H-imidazol-1-ylmethyl)-4-(2,4,4-trimethylpentan-2-yl)phenol, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total)
• Functional Keywords: oxidoreductase, isocitrate dehydrogenase inhibitor
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Cytoplasm : O75874
• Total number of polymer chains: 2
• Total formula weight: 98216.77

Authors

Mathieu, M.,Marquette, J.P. (deposition date: 2014-05-22, release date: 2014-11-19, Last modification date: 2024-01-10)

• Primary citation: Deng, G.,Shen, J.,Yin, M.,Mcmanus, J.,Mathieu, M.,Gee, P.,He, T.,Shi, C.,Bedel, O.,Mclean, L.R.,Le-Strat, F.,Zhang, Y.,Marquette, J.,Gao, Q.,Zhang, B.,Rak, A.,Hoffmann, D.,Rooney, E.,Vassort, A.,Englaro, W.,Li, Y.,Patel, V.,Adrian, F.,Gross, S.,Wiederschain, D.,Cheng, H.,Licht, S.; Selective Inhibition of Mutant Isocitrate Dehydrogenase 1 (Idh1) Via Disruption of a Metal Binding Network by an Allosteric Small Molecule.; J.Biol.Chem., 290:762-, 2015; PubMed: 25391653; DOI: 10.1074/JBC.M114.608497

Experimental method

X-RAY DIFFRACTION (1.88 Å)