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4UDW

Thrombin in complex with 1-(2R)-2-amino-3-phenyl-propanoyl-N-(2, 5dichlorophenyl)methylpyrrolidine-2-carboxamide

Summary for 4UDW
Entry DOI10.2210/pdb4udw/pdb
Related4UD9 4UDH 4UE7
DescriptorTHROMBIN HEAVY CHAIN, HIRUDIN VARIANT-2, THROMBIN LIGHT CHAIN, ... (9 entities in total)
Functional Keywordshydrolase, hydrolase inhibitor complex, serine protease, blood coagulation, blood clotting, convertion of fibrinogen to fibrin, blood clotting inhibitor, thrombin inhibitor, fragment, glycosylation, blood
Biological sourceHOMO SAPIENS (HUMAN)
More
Total number of polymer chains3
Total formula weight35334.96
Authors
Ruehmann, E.,Heine, A.,Klebe, G. (deposition date: 2014-12-12, release date: 2015-08-26, Last modification date: 2023-12-20)
Primary citationRuehmann, E.,Betz, M.,Heine, A.,Klebe, G.
Fragments Can Bind Either More Enthalpy or Entropy-Driven: Crystal Structures and Residual Hydration Pattern Suggest Why.
J.Med.Chem., 58:6960-, 2015
Cited by
PubMed: 26270568
DOI: 10.1021/ACS.JMEDCHEM.5B00812
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.16 Å)
Structure validation

217705

数据于2024-03-27公开中

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