4UAI

Crystal structure of CXCL12 in complex with inhibitor

Summary for 4UAI

Entry DOI	10.2210/pdb4uai/pdb
Descriptor	Stromal cell-derived factor 1, 1-phenyl-3-[4-(1H-tetrazol-5-yl)phenyl]urea, SULFATE ION, ... (4 entities in total)
Functional Keywords	cxcl12, inhibitor, complex, chemokine, cytokine-cytokine inhibitor complex, cytokine/cytokine inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	16429.33
Authors	Smith, E.W.,Chen, Y. (deposition date: 2014-08-09, release date: 2014-11-12, Last modification date: 2023-09-27)
Primary citation	Smith, E.W.,Liu, Y.,Getschman, A.E.,Peterson, F.C.,Ziarek, J.J.,Li, R.,Volkman, B.F.,Chen, Y. Structural Analysis of a Novel Small Molecule Ligand Bound to the CXCL12 Chemokine. J.Med.Chem., 57:9693-9699, 2014 Cited by PubMed: 25356720 DOI: 10.1021/jm501194p PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation