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4U7Q

Structure of wild-type HIV protease in complex with photosensitive inhibitor PDI-6

Summary for 4U7Q
Entry DOI10.2210/pdb4u7q/pdb
Related4U7V
DescriptorV-1 protease, N~2~-({[7-(diethylamino)-2-oxo-2H-chromen-4-yl]methoxy}carbonyl)-N-[(2S,4S,5S)-4-hydroxy-1,6-diphenyl-5-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}hexan-2-yl]-L-valinamide (3 entities in total)
Functional Keywordshiv-1, viral protease, aspartic protease, inhibition, hydrolase
Biological sourceHuman immunodeficiency virus 1
Total number of polymer chains2
Total formula weight22407.58
Authors
Pachl, P.,Rezacova, P.,Schimer, J. (deposition date: 2014-07-31, release date: 2015-03-25, Last modification date: 2023-12-20)
Primary citationSchimer, J.,Pavova, M.,Anders, M.,Pachl, P.,Sacha, P.,Cigler, P.,Weber, J.,Majer, P.,Rezacova, P.,Krausslich, H.G.,Muller, B.,Konvalinka, J.
Triggering HIV polyprotein processing by light using rapid photodegradation of a tight-binding protease inhibitor.
Nat Commun, 6:6461-6461, 2015
Cited by
PubMed: 25751579
DOI: 10.1038/ncomms7461
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.7 Å)
Structure validation

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