4U74

Crystal structure of 4-phenylimidazole bound form of human indoleamine 2,3-dioxygenase (G262A mutant)

Summary for 4U74

• Entry DOI: 10.2210/pdb4u74/pdb
• Related: 2D0T 2D0U 4U72
• Descriptor: Indoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, 4-PHENYL-1H-IMIDAZOLE, ... (5 entities in total)
• Functional Keywords: metal-binding, all alpha, oxidoreductase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 93711.50

Authors

Sugimoto, H.,Horitani, M.,Kometani, E.,Shiro, Y. (deposition date: 2014-07-30, release date: 2015-09-02, Last modification date: 2023-11-08)

• Primary citation: Horitani, M.,Kometani, E.,Vottero, E.,Otsuki, T.,Shiro, Y.,Sugimoto, H.; Conformation and Mobility of Active Site Loop is Critical for Substrate Binding and Inhibition in Human Indoleamine 2,3-Dioxygenase; to be published,

Experimental method

X-RAY DIFFRACTION (2.31 Å)