4TVK

TORPEDO CALIFORNICA ACETYLCHOLINESTERASE IN COMPLEX WITH A CHLOROTACRINE-JUGLONE HYBRID INHIBITOR

Summary for 4TVK

Entry DOI	10.2210/pdb4tvk/pdb
Descriptor	Acetylcholinesterase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
Functional Keywords	multitarget drug, enzyme-inhibitor complex, tacrine, quinone, hydrolase
Biological source	Torpedo californica (Pacific electric ray)
Cellular location	Isoform H: Cell membrane; Lipid-anchor, GPI- anchor. Isoform T: Cell membrane; Peripheral membrane protein: P04058
Total number of polymer chains	1
Total formula weight	61761.94
Authors	Pesaresi, A.,Samez, S.,Lamba, D. (deposition date: 2014-06-27, release date: 2014-10-08, Last modification date: 2023-12-20)
Primary citation	Nepovimova, E.,Uliassi, E.,Korabecny, J.,Pena-Altamira, L.E.,Samez, S.,Pesaresi, A.,Garcia, G.E.,Bartolini, M.,Andrisano, V.,Bergamini, C.,Fato, R.,Lamba, D.,Roberti, M.,Kuca, K.,Monti, B.,Bolognesi, M.L. Multitarget Drug Design Strategy: Quinone-Tacrine Hybrids Designed To Block Amyloid-beta Aggregation and To Exert Anticholinesterase and Antioxidant Effects. J.Med.Chem., 57:8576-8589, 2014 Cited by PubMed: 25259726 DOI: 10.1021/jm5010804 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation