4TTV

Crystal structure of human ThrRS complexing with a bioengineered macrolide BC194

Summary for 4TTV

• Entry DOI: 10.2210/pdb4ttv/pdb
• Descriptor: Threonine--tRNA ligase, cytoplasmic, (1R,2R)-2-[(2S,6E,8R,9S,11R,13S,15S,16S)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadec-6-en-2-yl]cyclobutanecarboxylic acid, ZINC ION, ... (4 entities in total)
• Functional Keywords: trna, synthetase, inhibitor, macrolide, ligase-antibiotic complex, ligase/antibiotic
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 195815.89

Authors

Fang, P.,Guo, M. (deposition date: 2014-06-23, release date: 2015-09-30, Last modification date: 2023-09-27)

• Primary citation: Mirando, A.C.,Fang, P.,Williams, T.F.,Baldor, L.C.,Howe, A.K.,Ebert, A.M.,Wilkinson, B.,Lounsbury, K.M.,Guo, M.,Francklyn, C.S.; Aminoacyl-tRNA synthetase dependent angiogenesis revealed by a bioengineered macrolide inhibitor.; Sci Rep, 5:13160-13160, 2015; PubMed: 26271225; DOI: 10.1038/srep13160

Experimental method

X-RAY DIFFRACTION (2.8 Å)