4TPW

The co-complex structure of the translation initiation factor eIF4E with the inhibitor 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G

Summary for 4TPW

Entry DOI	10.2210/pdb4tpw/pdb
Descriptor	Eukaryotic translation initiation factor 4E, 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE, (2E)-2-{2-[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazinylidene}-3-(2-nitrophenyl)propanoic acid, ... (5 entities in total)
Functional Keywords	eif4e, 4egi1, allosteric, translation initiation inhibitor, protein binding
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	46303.62
Authors	Papadopoulos, E.,Jenni, S.,Wagner, G. (deposition date: 2014-06-09, release date: 2014-08-13, Last modification date: 2023-09-27)
Primary citation	Papadopoulos, E.,Jenni, S.,Kabha, E.,Takrouri, K.J.,Yi, T.,Salvi, N.,Luna, R.E.,Gavathiotis, E.,Mahalingam, P.,Arthanari, H.,Rodriguez-Mias, R.,Yefidoff-Freedman, R.,Aktas, B.H.,Chorev, M.,Halperin, J.A.,Wagner, G. Structure of the eukaryotic translation initiation factor eIF4E in complex with 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G. Proc.Natl.Acad.Sci.USA, 111:E3187-E3195, 2014 Cited by PubMed: 25049413 DOI: 10.1073/pnas.1410250111 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation