4S15
Crystal structure of the orphan nuclear receptor RORalpha ligand-binding domain in complex with 4alpha-caboxyl, 4beta-methyl-zymosterol (4ACD8)
Summary for 4S15
| Entry DOI | 10.2210/pdb4s15/pdb |
| Related | 4S14 |
| Descriptor | Nuclear receptor ROR-alpha, Nuclear receptor-interacting protein 1, (3beta,4alpha,5beta,14beta)-3-hydroxy-4-methylcholesta-8,24-diene-4-carboxylic acid, ... (5 entities in total) |
| Functional Keywords | transcription factor, transcription |
| Biological source | Homo sapiens (human) More |
| Cellular location | Nucleus : P35398 P48552 |
| Total number of polymer chains | 4 |
| Total formula weight | 63521.81 |
| Authors | Huang, P.,Santori, F.R.,Littman, D.R.,Rastinejad, F. (deposition date: 2015-01-08, release date: 2015-02-11, Last modification date: 2024-02-28) |
| Primary citation | Santori, F.R.,Huang, P.,van de Pavert, S.A.,Douglass, E.F.,Leaver, D.J.,Haubrich, B.A.,Keber, R.,Lorbek, G.,Konijn, T.,Rosales, B.N.,Rozman, D.,Horvat, S.,Rahier, A.,Mebius, R.E.,Rastinejad, F.,Nes, W.D.,Littman, D.R. Identification of Natural ROR gamma Ligands that Regulate the Development of Lymphoid Cells. Cell Metab, 21:286-297, 2015 Cited by PubMed: 25651181DOI: 10.1016/j.cmet.2015.01.004 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.897 Å) |
Structure validation
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