4RXZ

Crystal Structure of MDMX phosporylated Tyr99 in complex with a 12-mer peptide

Summary for 4RXZ

• Entry DOI: 10.2210/pdb4rxz/pdb
• Related: 2Z5T 3DAC 3EQY
• Descriptor: Protein Mdm4, 12-MER PEPTIDE INHIBITOR (3 entities in total)
• Functional Keywords: mdm4, mdmx-peptide inhibitor complex, oncoprotein, metal-binding, pmi, inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: O15151
• Total number of polymer chains: 4
• Total formula weight: 22509.94

Authors

Pazgier, M.,Gohain, N.,Tolbert, W.D. (deposition date: 2014-12-12, release date: 2015-07-22, Last modification date: 2023-12-06)

• Primary citation: Chen, X.,Gohain, N.,Zhan, C.,Lu, W.Y.,Pazgier, M.,Lu, W.; Structural basis of how stress-induced MDMX phosphorylation activates p53.; Oncogene, 35:1919-1925, 2016; PubMed: 26148237; DOI: 10.1038/onc.2015.255

Experimental method

X-RAY DIFFRACTION (1.55 Å)