4RXQ

The structure of GTP-dUTP-bound SAMHD1

Summary for 4RXQ

• Entry DOI: 10.2210/pdb4rxq/pdb
• Descriptor: Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, GUANOSINE-5'-TRIPHOSPHATE, DEOXYURIDINE-5'-TRIPHOSPHATE, ... (5 entities in total)
• Functional Keywords: hd-domain, hydrolase, dntp and gtp binding, phosphorylation
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus : Q9Y3Z3
• Total number of polymer chains: 2
• Total formula weight: 127939.91

Authors

Zhu, C.F.,Wei, W.,Peng, X.,Dong, Y.H.,Gong, Y.,Yu, X.F. (deposition date: 2014-12-11, release date: 2015-03-11, Last modification date: 2023-09-20)

• Primary citation: Zhu, C.F.,Wei, W.,Peng, X.,Dong, Y.H.,Gong, Y.,Yu, X.F.; The mechanism of substrate-controlled allosteric regulation of SAMHD1 activated by GTP.; Acta Crystallogr.,Sect.D, 71:516-524, 2015; PubMed: 25760601; DOI: 10.1107/S1399004714027527

Experimental method

X-RAY DIFFRACTION (2.1 Å)