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4RWL

Crystal structure of FGFR1 (C488A, C584C) in complex with 6-(7-((1-aminocyclopropyl) methoxy)-6-methoxyquinolin-4-yloxy)-N-methyl-1-naphthamide (E3810)

Summary for 4RWL
Entry DOI10.2210/pdb4rwl/pdb
Related4RWI 4RWJ 4RWK
DescriptorFibroblast growth factor receptor 1, 6-({7-[(1-aminocyclopropyl)methoxy]-6-methoxyquinolin-4-yl}oxy)-N-methylnaphthalene-1-carboxamide, SULFATE ION, ... (4 entities in total)
Functional Keywordsreceptor tyrosine kinase, gatekeeper mutation, proto-oncogene, kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCell membrane; Single-pass type I membrane protein: P11362
Total number of polymer chains2
Total formula weight72992.76
Authors
Sohl, C.D.,Anderson, K.S. (deposition date: 2014-12-04, release date: 2015-04-15, Last modification date: 2023-09-20)
Primary citationSohl, C.D.,Ryan, M.R.,Luo, B.,Frey, K.M.,Anderson, K.S.
Illuminating the Molecular Mechanisms of Tyrosine Kinase Inhibitor Resistance for the FGFR1 Gatekeeper Mutation: The Achilles' Heel of Targeted Therapy.
Acs Chem.Biol., 10:1319-1329, 2015
Cited by
PubMed: 25686244
DOI: 10.1021/acschembio.5b00014
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.193 Å)
Structure validation

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