4RWI

Crystal structure of V561M FGFR1 gatekeeper mutation (C488A, C584S, V561M), apo

Summary for 4RWI

• Entry DOI: 10.2210/pdb4rwi/pdb
• Related: 4RWJ 4RWK 4RWL
• Descriptor: Fibroblast growth factor receptor 1 (2 entities in total)
• Functional Keywords: receptor tyrosine kinase, gatekeeper mutation, proto-oncogene, kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cell membrane; Single-pass type I membrane protein: P11362
• Total number of polymer chains: 2
• Total formula weight: 72517.33

Authors

Sohl, C.D.,Anderson, K.S. (deposition date: 2014-12-04, release date: 2015-04-15, Last modification date: 2023-09-20)

• Primary citation: Sohl, C.D.,Ryan, M.R.,Luo, B.,Frey, K.M.,Anderson, K.S.; Illuminating the Molecular Mechanisms of Tyrosine Kinase Inhibitor Resistance for the FGFR1 Gatekeeper Mutation: The Achilles' Heel of Targeted Therapy.; Acs Chem.Biol., 10:1319-1329, 2015; PubMed: 25686244; DOI: 10.1021/acschembio.5b00014

Experimental method

X-RAY DIFFRACTION (2.292 Å)