4RWG

Crystal structure of the CLR:RAMP1 extracellular domain heterodimer with bound high affinity CGRP analog

Summary for 4RWG

Entry DOI	10.2210/pdb4rwg/pdb
Related	4RWF
Related PRD ID	PRD_900001
Descriptor	Maltose-binding periplasmic protein, Receptor activity-modifying protein 1, Calcitonin gene-related peptide type 1 receptor fusion protein, CGRP analog, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, ... (5 entities in total)
Functional Keywords	cell surface receptor, membrane protein-hormone complex, membrane protein/hormone
Biological source	Escherichia coli More
Total number of polymer chains	6
Total formula weight	203547.95
Authors	Booe, J.,Pioszak, A. (deposition date: 2014-12-03, release date: 2015-05-20, Last modification date: 2023-09-20)
Primary citation	Booe, J.M.,Walker, C.S.,Barwell, J.,Kuteyi, G.,Simms, J.,Jamaluddin, M.A.,Warner, M.L.,Bill, R.M.,Harris, P.W.,Brimble, M.A.,Poyner, D.R.,Hay, D.L.,Pioszak, A.A. Structural Basis for Receptor Activity-Modifying Protein-Dependent Selective Peptide Recognition by a G Protein-Coupled Receptor. Mol.Cell, 58:1-13, 2015 Cited by PubMed: 25982113 DOI: 10.1016/j.molcel.2015.04.018 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.44 Å)

Structure validation