4RWF

Crystal structure of the CLR:RAMP2 extracellular domain heterodimer with bound adrenomedullin

Summary for 4RWF

• Entry DOI: 10.2210/pdb4rwf/pdb
• Related: 4RWG
• Related PRD ID: PRD_900001
• Descriptor: Maltose transporter subunit, Receptor activity-modifying protein 2, Calcitonin gene-related peptide type 1 receptor fusion protein, Adrenomedullin, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: cell surface receptor, membrane protein-hormone complex, membrane protein/hormone
• Biological source: Escherichia coli (human); More
• Total number of polymer chains: 2
• Total formula weight: 70213.65

Authors

Booe, J.,Pioszak, A. (deposition date: 2014-12-03, release date: 2015-05-20, Last modification date: 2020-07-29)

• Primary citation: Booe, J.M.,Walker, C.S.,Barwell, J.,Kuteyi, G.,Simms, J.,Jamaluddin, M.A.,Warner, M.L.,Bill, R.M.,Harris, P.W.,Brimble, M.A.,Poyner, D.R.,Hay, D.L.,Pioszak, A.A.; Structural Basis for Receptor Activity-Modifying Protein-Dependent Selective Peptide Recognition by a G Protein-Coupled Receptor.; Mol.Cell, 58:1-13, 2015; PubMed: 25982113; DOI: 10.1016/j.molcel.2015.04.018

Experimental method

X-RAY DIFFRACTION (1.76 Å)