4RME

Crystal structure of human Retinoid X receptor alpha ligand binding domain complex with 9cUAB111 and coactivator peptide GRIP-1

Summary for 4RME

Entry DOI	10.2210/pdb4rme/pdb
Related	3OAP 4K4J 4RMC
Descriptor	Retinoic acid receptor RXR-alpha, Nuclear receptor coactivator 2, (2E,4E,6Z,8E)-3,7-dimethyl-8-[2-(3-methylbutyl)-3-(propan-2-yl)cyclohex-2-en-1-ylidene]octa-2,4,6-trienoic acid, ... (4 entities in total)
Functional Keywords	ligand binding domain, cancer prevention, transcription
Biological source	Homo sapiens (human) More
Cellular location	Nucleus : P19793 Q15596
Total number of polymer chains	2
Total formula weight	28332.01
Authors	Xia, G.,Muccio, D.D. (deposition date: 2014-10-21, release date: 2015-09-16, Last modification date: 2023-09-20)
Primary citation	Atigadda, V.R.,Xia, G.,Deshpande, A.,Wu, L.,Kedishvili, N.,Smith, C.D.,Krontiras, H.,Bland, K.I.,Grubbs, C.J.,Brouillette, W.J.,Muccio, D.D. Conformationally Defined Rexinoids and Their Efficacy in the Prevention of Mammary Cancers. J.Med.Chem., 58:7763-7774, 2015 Cited by PubMed: 26331194 DOI: 10.1021/acs.jmedchem.5b00829 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation