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4RIL

Structure of the amyloid forming segment, GAVVTGVTAVA, from the NAC domain of Parkinson's disease protein alpha-synuclein, residues 68-78, determined by electron diffraction

Summary for 4RIL
Entry DOI10.2210/pdb4ril/pdb
EMDB information3028
DescriptorAlpha-synuclein (2 entities in total)
Functional Keywordsamyloid, alpha-synuclein, parkinson's disease, toxic core, nacore, lipid binding protein
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm, cytosol : P37840
Total number of polymer chains1
Total formula weight944.08
Authors
Primary citationRodriguez, J.A.,Ivanova, M.I.,Sawaya, M.R.,Cascio, D.,Reyes, F.E.,Shi, D.,Sangwan, S.,Guenther, E.L.,Johnson, L.M.,Zhang, M.,Jiang, L.,Arbing, M.A.,Nannenga, B.L.,Hattne, J.,Whitelegge, J.,Brewster, A.S.,Messerschmidt, M.,Boutet, S.,Sauter, N.K.,Gonen, T.,Eisenberg, D.S.
Structure of the toxic core of alpha-synuclein from invisible crystals.
Nature, 525:486-490, 2015
Cited by
PubMed: 26352473
DOI: 10.1038/nature15368
PDB entries with the same primary citation
Experimental method
ELECTRON CRYSTALLOGRAPHY (1.43 Å)
Structure validation

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