4RF0

Crystal structure of the Middle-East respiratory syndrome coronavirus papain-like protease in complex with ubiquitin (space group P6522)

Summary for 4RF0

• Entry DOI: 10.2210/pdb4rf0/pdb
• Related: 4REZ 4RF1
• Descriptor: ORF1ab protein, Ubiquitin-60S ribosomal protein L40, ZINC ION, ... (6 entities in total)
• Functional Keywords: zinc ribbon, deubiquitinase, papain-like protease, protein binding
• Biological source: Human betacoronavirus 2c Jordan-N3/2012; More
• Cellular location: Host cytoplasm, host perinuclear region . Host membrane ; Multi-pass membrane protein : M4STU1; Ubiquitin: Cytoplasm . 60S ribosomal protein L40: Cytoplasm : P62987
• Total number of polymer chains: 2
• Total formula weight: 45555.33

Authors

Bailey-Elkin, B.A.,Johnson, G.G.,Mark, B.L. (deposition date: 2014-09-24, release date: 2014-10-22, Last modification date: 2015-01-14)

• Primary citation: Bailey-Elkin, B.A.,Knaap, R.C.,Johnson, G.G.,Dalebout, T.J.,Ninaber, D.K.,van Kasteren, P.B.,Bredenbeek, P.J.,Snijder, E.J.,Kikkert, M.,Mark, B.L.; Crystal Structure of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Papain-like Protease Bound to Ubiquitin Facilitates Targeted Disruption of Deubiquitinating Activity to Demonstrate Its Role in Innate Immune Suppression.; J.Biol.Chem., 289:34667-34682, 2014; PubMed: 25320088; DOI: 10.1074/jbc.M114.609644

Experimental method

X-RAY DIFFRACTION (2.8 Å)