4RAK

Crystal structure of nuclear receptor subfamily 1, group h, member 2 (lxrb) complexed with partial agonist

Summary for 4RAK

Entry DOI	10.2210/pdb4rak/pdb
Descriptor	Oxysterols receptor LXR-beta, 1,4-BUTANEDIOL, 2-{2-[2-(2-chlorophenyl)propan-2-yl]-1-[3'-(methylsulfonyl)biphenyl-4-yl]-1H-imidazol-4-yl}propan-2-ol, ... (4 entities in total)
Functional Keywords	nhr, nr1h2, lxr-b, lxrb, unr, ner-i, rip15, ner, ligand binding domain, nuclear hormone receptor, rxr, transcription-agonist complex, transcription/agonist
Biological source	Homo sapiens (human)
Cellular location	Nucleus : P55055
Total number of polymer chains	2
Total formula weight	62374.19
Authors	Nanao, M. (deposition date: 2014-09-10, release date: 2014-12-31, Last modification date: 2024-02-28)
Primary citation	Kick, E.,Martin, R.,Xie, Y.,Flatt, B.,Schweiger, E.,Wang, T.L.,Busch, B.,Nyman, M.,Gu, X.H.,Yan, G.,Wagner, B.,Nanao, M.,Nguyen, L.,Stout, T.,Plonowski, A.,Schulman, I.,Ostrowski, J.,Kirchgessner, T.,Wexler, R.,Mohan, R. Liver X Receptor (LXR) partial agonists: Biaryl pyrazoles and imidazoles displaying a preference for LXR beta. Bioorg.Med.Chem.Lett., 25:372-377, 2015 Cited by PubMed: 25435151 DOI: 10.1016/j.bmcl.2014.11.029 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.04 Å)

Structure validation