4RA3
Crystal structure of dimeric S33C beta-2 microglobulin mutant in complex with Thioflavin (ThT) at 2.8 Angstrom resolution
Summary for 4RA3
Entry DOI | 10.2210/pdb4ra3/pdb |
Related | 4R9H 4RAH |
Descriptor | Beta-2-microglobulin, 2-[4-(dimethylamino)phenyl]-3,6-dimethyl-1,3-benzothiazol-3-ium (2 entities in total) |
Functional Keywords | amyloidosis, protein aggregation, thioflavin, covalent dimer, oligomerization, beta sandwich, inclusion bodies, immune system |
Biological source | Homo sapiens (human) |
Cellular location | Secreted . Note=(Microbial infection) In the presence of M: P61769 |
Total number of polymer chains | 4 |
Total formula weight | 48998.74 |
Authors | Halabelian, L.,Bolognesi, M.,Ricagno, S. (deposition date: 2014-09-09, release date: 2015-09-09, Last modification date: 2023-09-20) |
Primary citation | Halabelian, L.,Relini, A.,Barbiroli, A.,Penco, A.,Bolognesi, M.,Ricagno, S. A covalent homodimer probing early oligomers along amyloid aggregation. Sci Rep, 5:14651-14651, 2015 Cited by PubMed: 26420657DOI: 10.1038/srep14651 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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