4R3M

Crystal structure of Human Hsp90 with JR9

Summary for 4R3M

Entry DOI	10.2210/pdb4r3m/pdb
Descriptor	Heat shock protein HSP 90-alpha, N~3~-benzyl-2-[(6-bromo-1,3-benzodioxol-5-yl)methyl]imidazo[1,2-a]pyrazine-3,8-diamine (3 entities in total)
Functional Keywords	chaperone/chaperone inhibitor, chaperone-chaperone inhibitor complex
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P07900
Total number of polymer chains	1
Total formula weight	23844.82
Authors	Li, J.,Yang, M.,Ren, J.,Xiong, B.,He, J. (deposition date: 2014-08-16, release date: 2014-11-05, Last modification date: 2024-03-20)
Primary citation	Ren, J.,Yang, M.,Liu, H.,Cao, D.,Chen, D.,Li, J.,Tang, L.,He, J.,Chen, Y.L.,Geng, M.,Xiong, B.,Shen, J. Multi-substituted 8-aminoimidazo[1,2-a]pyrazines by Groebke-Blackburn-Bienayme reaction and their Hsp90 inhibitory activity. Org.Biomol.Chem., 13:1531-1535, 2015 Cited by PubMed: 25490978 DOI: 10.1039/c4ob01865f PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation