4QYA

Crystal structure of human transthyretin variant V30M in complex with luteolin

Summary for 4QYA

• Entry DOI: 10.2210/pdb4qya/pdb
• Descriptor: Transthyretin, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one, SODIUM ION, ... (4 entities in total)
• Functional Keywords: amyloid fibrils, transport protein, vitamin a, retinol-binding protein
• Biological source: Homo sapiens (human)
• Cellular location: Secreted: P02766
• Total number of polymer chains: 2
• Total formula weight: 28214.31

Authors

Begum, A.,Olofsson, A.,Sauer-Eriksson, A.E. (deposition date: 2014-07-24, release date: 2015-06-03, Last modification date: 2024-02-28)

• Primary citation: Iakovleva, I.,Begum, A.,Pokrzywa, M.,Walfridsson, M.,Sauer-Eriksson, A.E.,Olofsson, A.; The flavonoid luteolin, but not luteolin-7-o-glucoside, prevents a transthyretin mediated toxic response.; Plos One, 10:e0128222-e0128222, 2015; PubMed: 26020516; DOI: 10.1371/journal.pone.0128222

Experimental method

X-RAY DIFFRACTION (1.7 Å)