4QXV

CRYSTAL STRUCTURE of HUMAN TRANSTHYRETIN IN COMPLEX WITH LUTEOLIN AT 1.1 A RESOLUTION

Summary for 4QXV

• Entry DOI: 10.2210/pdb4qxv/pdb
• Related: 1F41 1G1O 1SOK 1ZD6
• Descriptor: Transthyretin, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one, GLYCEROL, ... (5 entities in total)
• Functional Keywords: beta barrel, wild type ttr, transthyretin, transport protein
• Biological source: Homo sapiens (human)
• Cellular location: Secreted: P02766
• Total number of polymer chains: 2
• Total formula weight: 28426.46

Authors

Begum, A.,Olofsson, A.,Sauer-Eriksson, A.E. (deposition date: 2014-07-22, release date: 2015-06-03, Last modification date: 2023-09-20)

• Primary citation: Iakovleva, I.,Begum, A.,Pokrzywa, M.,Walfridsson, M.,Sauer-Eriksson, A.E.,Olofsson, A.; The flavonoid luteolin, but not luteolin-7-o-glucoside, prevents a transthyretin mediated toxic response.; Plos One, 10:e0128222-e0128222, 2015; PubMed: 26020516; DOI: 10.1371/journal.pone.0128222

Experimental method

X-RAY DIFFRACTION (1.12 Å)