4QU8

Caspase-3 M61A V266H

Summary for 4QU8

Entry DOI	10.2210/pdb4qu8/pdb
Related	4QTX 4QTY 4QU0 4QU5 4QU9 4QUA 4QUB 4QUD 4QUE 4QUG 4QUH 4QUI 4QUJ 4QUL
Related PRD ID	PRD_000238
Descriptor	Caspase-3, ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR, CHLORIDE ION, ... (5 entities in total)
Functional Keywords	allosteric network, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P42574
Total number of polymer chains	2
Total formula weight	32493.63
Authors	Cade, C.,Swartz, P.D.,MacKenzie, S.H.,Clark, A.C. (deposition date: 2014-07-10, release date: 2014-11-05, Last modification date: 2017-11-22)
Primary citation	Cade, C.,Swartz, P.,MacKenzie, S.H.,Clark, A.C. Modifying caspase-3 activity by altering allosteric networks. Biochemistry, 53:7582-7595, 2014 Cited by PubMed: 25343534 DOI: 10.1021/bi500874k PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.715 Å)

Structure validation