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4QRE

Structure of Methionyl-tRNA Synthetase in complex with 1-(4-{4-[(1H-benzimidazol-2-ylmethyl)amino]-6-(4,5-dimethoxy-2-methylphenoxy)pyrimidin-2-yl}piperazin-1-yl)ethanone

Summary for 4QRE
Entry DOI10.2210/pdb4qre/pdb
Related4QRD
DescriptorMethionyl-tRNA synthetase, 1-(4-{4-[(1H-benzimidazol-2-ylmethyl)amino]-6-(4,5-dimethoxy-2-methylphenoxy)pyrimidin-2-yl}piperazin-1-yl)ethanone, ADENOSINE-5'-TRIPHOSPHATE, ... (5 entities in total)
Functional Keywordsprotein synthesis, aminoacyl-trna synthetase, aminoacylation, cytosol, ligase-ligase inhibitor complex, ligase/ligase inhibitor
Biological sourceStaphylococcus aureus
Total number of polymer chains1
Total formula weight64190.61
Authors
Hilgers, M.T. (deposition date: 2014-06-30, release date: 2015-07-29, Last modification date: 2024-02-28)
Primary citationLi, X.,Hilgers, M.T.,Stidham, M.,Brown-Driver, V.,Shaw, K.J.,Finn, J.
Discovery and SAR of a Novel Series of Pyrimidine Antibacterials Targeting Methionyl-tRNA Synthetase
to be published,
Experimental method
X-RAY DIFFRACTION (1.7 Å)
Structure validation

217705

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