4QR3
Brd4 Bromodomain 1 complex with its novel inhibitors
Summary for 4QR3
| Entry DOI | 10.2210/pdb4qr3/pdb |
| Related | 4QR4 4QR5 |
| Descriptor | Bromodomain-containing protein 4, N-cyclopentyl-3-(2-oxo-2,3-dihydro-1,3-thiazol-4-yl)benzenesulfonamide (3 entities in total) |
| Functional Keywords | brd4, bromodomain, four alpha helices, transcription-transcription inhibitor complex, transcription/transcription inhibitor |
| Biological source | Homo sapiens (human) |
| Cellular location | Nucleus: O60885 |
| Total number of polymer chains | 1 |
| Total formula weight | 15165.57 |
| Authors | Xiong, B.,Cao, D.Y.,Chen, T.T.,Xu, Y.C. (deposition date: 2014-06-30, release date: 2015-07-01, Last modification date: 2024-03-20) |
| Primary citation | Zhao, L.,Wang, Y.,Cao, D.Y.,Chen, T.T.,Wang, Q.,Li, Y.,Xu, Y.C.,Zhang, N.,Wang, X.,Chen, D.,Chen, L.,Chen, Y.L.,Xia, G.,Shi, Z.,Liu, Y.C.,Lin, Y.,Miao, Z.,Shen, J.,Xiong, B. Fragment-based drug discovery of 2-thiazolidinones as BRD4 inhibitors: 2. Structure-based optimization J.Med.Chem., 58:1281-1297, 2015 Cited by PubMed: 25559428DOI: 10.1021/jm501504k PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.374 Å) |
Structure validation
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