4QO4

co-crystal structure of MDM2 (17-111) with compound 16, {(3R,5R,6S)-5-(3-CHLOROPHENYL)-6-(4-CHLOROPHENYL)-1-[(1S)-1-(6-CYCLOPROPYLPYRIDIN-2-YL)PROPYL]-3-METHYL-2-OXOPIPERIDIN-3-YL}ACETIC ACID

Summary for 4QO4

• Entry DOI: 10.2210/pdb4qo4/pdb
• Related: 4QOC
• Descriptor: E3 ubiquitin-protein ligase Mdm2, {(3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-[(1S)-1-(6-cyclopropylpyridin-2-yl)propyl]-3-methyl-2-oxopiperidin-3-yl}acetic acid (3 entities in total)
• Functional Keywords: mdm2, p53, protein-protein interaction, inhibitor, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus, nucleoplasm: Q00987
• Total number of polymer chains: 1
• Total formula weight: 11707.56

Authors

Huang, X. (deposition date: 2014-06-19, release date: 2014-07-16, Last modification date: 2024-02-28)

• Primary citation: Yu, M.,Wang, Y.,Zhu, J.,Bartberger, M.D.,Canon, J.,Chen, A.,Chow, D.,Eksterowicz, J.,Fox, B.,Fu, J.,Gribble, M.,Huang, X.,Li, Z.,Liu, J.J.,Lo, M.C.,McMinn, D.,Oliner, J.D.,Osgood, T.,Rew, Y.,Saiki, A.Y.,Shaffer, P.,Yan, X.,Ye, Q.,Yu, D.,Zhao, X.,Zhou, J.,Olson, S.H.,Medina, J.C.,Sun, D.; Discovery of Potent and Simplified Piperidinone-Based Inhibitors of the MDM2-p53 Interaction.; ACS Med Chem Lett, 5:894-899, 2014; PubMed: 25147610; DOI: 10.1021/ml500142b

Experimental method

X-RAY DIFFRACTION (1.7 Å)