4QHU

Crystal Structure of IL-17A/Fab6785 complex

Summary for 4QHU

• Entry DOI: 10.2210/pdb4qhu/pdb
• Descriptor: Fab6785 light chain, Fab6785 heavy chain, Interleukin-17A, ... (7 entities in total)
• Functional Keywords: antibody-antigen interaction, receptor differentiation, molecular asymmetry, cystine knot, cytokine il-17, il-17ra, il-17rc, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: Q16552
• Total number of polymer chains: 6
• Total formula weight: 124652.31

Authors

Luo, J.,Gilliland, G.L.,Malia, T.,Obmolova, G.,Teplyakov, A. (deposition date: 2014-05-29, release date: 2015-08-05)

• Primary citation: Luo, J.,Gilliland, G.L.,Malia, T.,Obmolova, G.,Teplyakov, A.; IL-17A Asymmetry in a Complex with a Neutralizing Antibody Fab6785 Reveals a Potential Mechanism of Receptor Differentiation; To be Published,

Experimental method

X-RAY DIFFRACTION (2.2 Å)