4Q23

The role of threonine 201 and tyrosine 204 in the human farnesyl pyrophosphate synthase catalytic mechanism and the mode of inhibition by the nitrogen-containing bisphosphonates

Summary for 4Q23

• Entry DOI: 10.2210/pdb4q23/pdb
• Related: 4KFA 4KPD 4KPJ 4KQ5 4KQS 4KQU
• Descriptor: Farnesyl pyrophosphate synthase, 1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACID, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: isoprene biosynthesis, lipid synthesis, steroid biosynthesis, transferase, isoprenoid pathway, cholesterol synthesis, bisphosphonates, alpha helical prenyltransferase, isopentyl pyrophosphate, dimethylallyl pyrophospahte
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P14324
• Total number of polymer chains: 1
• Total formula weight: 43567.05

Authors

Tsoumpra, M.K.,Muniz, J.R.C.,Barnett, B.L.,Kwaasi, A.A.,Pilka, E.S.,Kavanagh, K.L.,Evdokimov, A.,Walter, R.L.,Ebetino, F.H.,von Delft, F.,Oppermann, U.,Russell, R.G.G.,Dunford, J.E. (deposition date: 2014-04-05, release date: 2015-03-18, Last modification date: 2023-09-20)

• Primary citation: Tsoumpra, M.K.,Muniz, J.R.C.,Barnett, B.L.,Kwaasi, A.A.,Pilka, E.S.,Kavanagh, K.L.,Evdokimov, A.,Walter, R.L.,Ebetino, F.H.,von Delft, F.,Oppermann, U.,Russell, R.G.G.,Dunford, J.E.; The role of threonine 201 and tyrosine 204 in the human farnesyl pyrophosphate synthase catalytic mechanism and the mode of inhibition by the nitrogen-containing bisphosphonates; To be Published,

Experimental method

X-RAY DIFFRACTION (1.98 Å)