Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

4Q1N

Structure-based design of 4-hydroxy-3,5-substituted piperidines as direct renin inhibitors

Summary for 4Q1N
Entry DOI10.2210/pdb4q1n/pdb
Related4PYV
DescriptorRenin, DIMETHYL SULFOXIDE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
Functional Keywordsaspartic protease, angiotensin, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationSecreted: P00797
Total number of polymer chains2
Total formula weight76255.07
Authors
Schiering, N.,D'Arcy, A.,Irie, O.,Yokokawa, F. (deposition date: 2014-04-04, release date: 2014-08-06, Last modification date: 2020-07-29)
Primary citationEhara, T.,Irie, O.,Kosaka, T.,Kanazawa, T.,Breitenstein, W.,Grosche, P.,Ostermann, N.,Suzuki, M.,Kawakami, S.,Konishi, K.,Hitomi, Y.,Toyao, A.,Gunji, H.,Cumin, F.,Schiering, N.,Wagner, T.,Rigel, D.F.,Webb, R.L.,Maibaum, J.,Yokokawa, F.
Structure-based design of substituted piperidines as a new class of highly efficacious oral direct Renin inhibitors.
ACS Med Chem Lett, 5:787-792, 2014
Cited by
PubMed: 25050166
DOI: 10.1021/ml500137b
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.09 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon