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4PYW

1.92 angstrom crystal structure of A1AT:TTAI ternary complex

Summary for 4PYW
Entry DOI10.2210/pdb4pyw/pdb
DescriptorAlpha-1-antitrypsin, ACE-THR-THR-ALA-ILE-NH2, GLYCEROL, ... (4 entities in total)
Functional Keywordsserpin, hydrolase inhibitor
Biological sourceHomo sapiens (human)
More
Cellular locationSecreted. Short peptide from AAT: Secreted, extracellular space, extracellular matrix: P01009
Total number of polymer chains3
Total formula weight46652.94
Authors
Nyon, M.P.,Day, J.,Gooptu, B. (deposition date: 2014-03-28, release date: 2015-06-10, Last modification date: 2022-08-24)
Primary citationNyon, M.P.,Prentice, T.,Day, J.,Kirkpatrick, J.,Sivalingam, G.N.,Levy, G.,Haq, I.,Irving, J.A.,Lomas, D.A.,Christodoulou, J.,Gooptu, B.,Thalassinos, K.
An integrative approach combining ion mobility mass spectrometry, X-ray crystallography, and nuclear magnetic resonance spectroscopy to study the conformational dynamics of alpha 1 -antitrypsin upon ligand binding.
Protein Sci., 24:1301-1312, 2015
Cited by
PubMed: 26011795
DOI: 10.1002/pro.2706
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.91 Å)
Structure validation

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