4PY2

Crystal structure of methionyl-tRNA synthetase MetRS from Brucella melitensis in complex with inhibitor 1-{3-[(3,5-DICHLOROBENZYL)AMINO]PROPYL}-3-THIOPHEN-3-YLUREA

Summary for 4PY2

• Entry DOI: 10.2210/pdb4py2/pdb
• Related: 4DLP 4LNE 4PPW
• Descriptor: Methionine--tRNA ligase, 1-{3-[(3,5-dichlorobenzyl)amino]propyl}-3-thiophen-3-ylurea, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: structural genomics, niaid, national institute of allergy and infectious diseases, seattle structural genomics center for infectious disease, ssgcid, ligase, methionyl-trna synthetase, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• Biological source: Brucella melitensis
• Cellular location: Cytoplasm : Q2YQ76
• Total number of polymer chains: 3
• Total formula weight: 182522.63

Authors

Seattle Structural Genomics Center for Infectious Disease,Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2014-03-25, release date: 2015-04-15, Last modification date: 2023-09-20)

• Primary citation: Ojo, K.K.,Ranade, R.M.,Zhang, Z.,Dranow, D.M.,Myers, J.B.,Choi, R.,Nakazawa Hewitt, S.,Edwards, T.E.,Davies, D.R.,Lorimer, D.,Boyle, S.M.,Barrett, L.K.,Buckner, F.S.,Fan, E.,Van Voorhis, W.C.; Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis.; Plos One, 11:e0160350-e0160350, 2016; PubMed: 27500735; DOI: 10.1371/journal.pone.0160350

Experimental method

X-RAY DIFFRACTION (2.15 Å)