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4PY0

Crystal structure of P2Y12 receptor in complex with 2MeSATP

Summary for 4PY0
Entry DOI10.2210/pdb4py0/pdb
Related4NTJ 4PXZ
DescriptorP2Y purinoceptor 12, Soluble cytochrome b562, 2-(methylsulfanyl)adenosine 5'-(tetrahydrogen triphosphate), (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ... (4 entities in total)
Functional Keywordspurinergic receptor p2y12, partial agonist-bound, g-protein coupled receptor (gpcr), membrane protein, signaling protein-nucleotide complex, psi-biology, gpcr network, structural genomics, signaling membrane protein, gpcr, platelet activation, membrane
Biological sourceHomo sapiens (human)
More
Cellular locationCell membrane ; Multi-pass membrane protein : Q9H244
Total number of polymer chains1
Total formula weight54515.23
Authors
Primary citationZhang, J.,Zhang, K.,Gao, Z.G.,Paoletta, S.,Zhang, D.,Han, G.W.,Li, T.,Ma, L.,Zhang, W.,Muller, C.E.,Yang, H.,Jiang, H.,Cherezov, V.,Katritch, V.,Jacobson, K.A.,Stevens, R.C.,Wu, B.,Zhao, Q.
Agonist-bound structure of the human P2Y12 receptor
Nature, 509:119-122, 2014
Cited by
PubMed: 24784220
DOI: 10.1038/nature13288
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.1 Å)
Structure validation

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