4PPP

Crystal Structure of the Estrogen Receptor alpha Ligand-binding Domain in Complex with Fluoro-Resveratrol

Summary for 4PPP

Entry DOI	10.2210/pdb4ppp/pdb
Related	4PP6 4PPS
Descriptor	Estrogen receptor, Nuclear receptor coactivator 2, 5-[(E)-2-(3-fluoro-4-hydroxyphenyl)ethenyl]benzene-1,3-diol, ... (4 entities in total)
Functional Keywords	nuclear hormone receptor, transcription factor, ligand-binding, nucleus, protein binding
Biological source	Homo sapiens (human) More
Cellular location	Isoform 1: Nucleus. Isoform 3: Nucleus. Nucleus: P03372 Nucleus: Q15596
Total number of polymer chains	4
Total formula weight	58434.80
Authors	Nwachukwu, J.C.,Srinivasan, S.,Bruno, N.E.,Parent, A.A.,Hughes, T.S.,Pollock, J.A.,Gjyshi, O.,Cavett, V.,Nowak, J.,Garcia-Ordonez, R.D.,Houtman, R.,Griffin, P.R.,Kojetin, D.J.,Katzenellenbogen, J.A.,Conkright, M.D.,Nettles, K.W. (deposition date: 2014-02-27, release date: 2014-05-07, Last modification date: 2023-09-20)
Primary citation	Nwachukwu, J.C.,Srinivasan, S.,Bruno, N.E.,Parent, A.A.,Hughes, T.S.,Pollock, J.A.,Gjyshi, O.,Cavett, V.,Nowak, J.,Garcia-Ordonez, R.D.,Houtman, R.,Griffin, P.R.,Kojetin, D.J.,Katzenellenbogen, J.A.,Conkright, M.D.,Nettles, K.W. Resveratrol modulates the inflammatory response via an estrogen receptor-signal integration network. Elife, 3:e02057-e02057, 2014 Cited by PubMed: 24771768 DOI: 10.7554/eLife.02057 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.686 Å)

Structure validation