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4POD

Structure of Triosephosphate Isomerase I170V mutant human enzyme.

Summary for 4POD
Entry DOI10.2210/pdb4pod/pdb
Related4POC
DescriptorTriosephosphate isomerase, POTASSIUM ION, SODIUM ION, ... (6 entities in total)
Functional Keywordstim alpha/beta barrel, tim barrel, isomerase, glycolytic
Biological sourceHomo sapiens (human)
Total number of polymer chains2
Total formula weight54700.03
Authors
Amrich, C.G.,Aslam, A.A.,Heroux, A.,VanDemark, A.P. (deposition date: 2014-02-25, release date: 2015-01-14, Last modification date: 2023-09-20)
Primary citationRoland, B.P.,Amrich, C.G.,Kammerer, C.J.,Stuchul, K.A.,Larsen, S.B.,Rode, S.,Aslam, A.A.,Heroux, A.,Wetzel, R.,VanDemark, A.P.,Palladino, M.J.
Triosephosphate isomerase I170V alters catalytic site, enhances stability and induces pathology in a Drosophila model of TPI deficiency.
Biochim.Biophys.Acta, 1852:61-69, 2015
Cited by
PubMed: 25463631
DOI: 10.1016/j.bbadis.2014.10.010
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.99 Å)
Structure validation

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