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4PMP

The structure of TrkA kinase bound to the inhibitor 1-cyclopropyl-1-[3-(1,3-thiazol-2-yl)benzyl]-3-[4-(trifluoromethoxy)phenyl]urea

Summary for 4PMP
Entry DOI10.2210/pdb4pmp/pdb
Related4PMM 4PMS 4PMT
DescriptorHigh affinity nerve growth factor receptor, 1-cyclopropyl-1-[3-(1,3-thiazol-2-yl)benzyl]-3-[4-(trifluoromethoxy)phenyl]urea, CHLORIDE ION, ... (5 entities in total)
Functional Keywordskinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationCell membrane ; Single-pass type I membrane protein : P04629
Total number of polymer chains1
Total formula weight33878.40
Authors
Su, H.P. (deposition date: 2014-05-22, release date: 2014-06-18, Last modification date: 2023-12-27)
Primary citationStachel, S.J.,Sanders, J.M.,Henze, D.A.,Rudd, M.T.,Su, H.P.,Li, Y.,Nanda, K.K.,Egbertson, M.S.,Manley, P.J.,Jones, K.L.,Brnardic, E.J.,Green, A.,Grobler, J.A.,Hanney, B.,Leitl, M.,Lai, M.T.,Munshi, V.,Murphy, D.,Rickert, K.,Riley, D.,Krasowska-Zoladek, A.,Daley, C.,Zuck, P.,Kane, S.A.,Bilodeau, M.T.
Maximizing diversity from a kinase screen: identification of novel and selective pan-Trk inhibitors for chronic pain.
J.Med.Chem., 57:5800-5816, 2014
Cited by
PubMed: 24914455
DOI: 10.1021/jm5006429
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation

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