4PIV

Human Fatty Acid Synthase Psi/KR Tri-Domain with NADPH and GSK2194069

Summary for 4PIV

Entry DOI	10.2210/pdb4piv/pdb
Descriptor	Fatty acid synthase, CACODYLATE ION, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (6 entities in total)
Functional Keywords	fatty acid synthase, human fas, keto-reductase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	146702.41
Authors	Williams, S.P.,Wang, L.,Brown, K.K.,Parrish, C.A.,Hardwicke, M.A. (deposition date: 2014-05-09, release date: 2014-07-23, Last modification date: 2023-12-27)
Primary citation	Hardwicke, M.A.,Rendina, A.R.,Williams, S.P.,Moore, M.L.,Wang, L.,Krueger, J.A.,Plant, R.N.,Totoritis, R.D.,Zhang, G.,Briand, J.,Burkhart, W.A.,Brown, K.K.,Parrish, C.A. A human fatty acid synthase inhibitor binds beta-ketoacyl reductase in the keto-substrate site. Nat.Chem.Biol., 10:774-779, 2014 Cited by PubMed: 25086508 DOI: 10.1038/nchembio.1603 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.299 Å)

Structure validation