4PCW

Crystal Structure of the N-terminal Domain of Human Profilaggrin at 2.2 A Resolution

Summary for 4PCW

Entry DOI	10.2210/pdb4pcw/pdb
Descriptor	Filaggrin, CALCIUM ION, NONAETHYLENE GLYCOL, ... (4 entities in total)
Functional Keywords	s100 protein, ef-hand calcium binding protein, epidermal skin protein, signaling protein, metal binding protein
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasmic granule : P20930
Total number of polymer chains	4
Total formula weight	45993.19
Authors	Bunick, C.G.,Steitz, T.A. (deposition date: 2014-04-16, release date: 2015-04-01, Last modification date: 2023-09-27)
Primary citation	Bunick, C.G.,Presland, R.B.,Lawrence, O.T.,Pearton, D.J.,Milstone, L.M.,Steitz, T.A. Crystal Structure of Human Profilaggrin S100 Domain and Identification of Target Proteins Annexin II, Stratifin, and HSP27. J. Invest. Dermatol., 135:1801-1809, 2015 Cited by PubMed: 25760235 DOI: 10.1038/jid.2015.102 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation