4PCI

Crystal Structure of the first bromodomain of BRD4 in complex with B16

Summary for 4PCI

Entry DOI	10.2210/pdb4pci/pdb
Related	4PCE
Descriptor	Bromodomain-containing protein 4, (4S)-1-methyl-4-phenyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	transcription-transcription inhibitor complex, transcription/transcription inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Nucleus: O60885
Total number of polymer chains	1
Total formula weight	15413.76
Authors	Dong, J.,Caflisch, A. (deposition date: 2014-04-15, release date: 2014-05-14, Last modification date: 2023-09-27)
Primary citation	Zhao, H.,Gartenmann, L.,Dong, J.,Spiliotopoulos, D.,Caflisch, A. Discovery of BRD4 bromodomain inhibitors by fragment-based high-throughput docking. Bioorg.Med.Chem.Lett., 24:2493-2496, 2014 Cited by PubMed: 24767840 DOI: 10.1016/j.bmcl.2014.04.017 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.25 Å)

Structure validation