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4P73

PheRS in complex with compound 1a

Summary for 4P73
Entry DOI10.2210/pdb4p73/pdb
Related4P71 4P72 4P74 4P75
DescriptorPhenylalanine--tRNA ligase beta subunit, Phenylalanine--tRNA ligase alpha subunit, 1-{3-[(4-pyridin-2-ylpiperazin-1-yl)sulfonyl]phenyl}-3-(1,3-thiazol-2-yl)urea, ... (4 entities in total)
Functional Keywordsphenylalanyl-trna synthetase, phers, ligase-ligase inhibitor complex, ligase/ligase inhibitor
Biological sourcePseudomonas aeruginosa
More
Cellular locationCytoplasm : Q9I0A4 Q9I0A3
Total number of polymer chains4
Total formula weight250916.54
Authors
Ferguson, A.D. (deposition date: 2014-03-25, release date: 2014-06-25, Last modification date: 2023-09-27)
Primary citationAbibi, A.,Ferguson, A.D.,Fleming, P.R.,Gao, N.,Hajec, L.I.,Hu, J.,Laganas, V.A.,McKinney, D.C.,McLeod, S.M.,Prince, D.B.,Shapiro, A.B.,Buurman, E.T.
The role of a novel auxiliary pocket in bacterial phenylalanyl-tRNA synthetase druggability.
J.Biol.Chem., 289:21651-21662, 2014
Cited by
PubMed: 24936059
DOI: 10.1074/jbc.M114.574061
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.03 Å)
Structure validation

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