4P5O

Structure of an RBX1-UBC12~NEDD8-CUL1-DCN1 complex: a RING-E3-E2~ubiquitin-like protein-substrate intermediate trapped in action

Summary for 4P5O

Entry DOI	10.2210/pdb4p5o/pdb
Descriptor	Cullin-1, E3 ubiquitin-protein ligase RBX1, DCN1-like protein 1, ... (6 entities in total)
Functional Keywords	nedd8, cullin, neddylation, complex, ubc12, dcn1, ubiquitin, ligase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	10
Total formula weight	217839.00
Authors	Scott, D.C.,Schulman, B.A. (deposition date: 2014-03-18, release date: 2014-07-02, Last modification date: 2023-12-27)
Primary citation	Scott, D.C.,Sviderskiy, V.O.,Monda, J.K.,Lydeard, J.R.,Cho, S.E.,Harper, J.W.,Schulman, B.A. Structure of a RING E3 Trapped in Action Reveals Ligation Mechanism for the Ubiquitin-like Protein NEDD8. Cell, 157:1671-1684, 2014 Cited by PubMed: 24949976 DOI: 10.1016/j.cell.2014.04.037 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.1071 Å)

Structure validation