4P2C
Complex of Shiga toxin 2e with a neutralizing single-domain antibody
Summary for 4P2C
| Entry DOI | 10.2210/pdb4p2c/pdb |
| Descriptor | Shiga toxin 2e, subunit A, Shiga toxin 2e, subunit B, Nanobody 1, Anti-F4+ETEC bacteria VHH variable region (3 entities in total) |
| Functional Keywords | nanobody, toxin, complex, lectin |
| Biological source | Escherichia coli More |
| Total number of polymer chains | 11 |
| Total formula weight | 141947.46 |
| Authors | Lo, A.W.H.,Moonens, K.,De Kerpel, M.,Brys, L.,Pardon, E.,Remaut, H.,De Greve, H. (deposition date: 2014-03-03, release date: 2014-07-30, Last modification date: 2023-12-27) |
| Primary citation | Lo, A.W.,Moonens, K.,De Kerpel, M.,Brys, L.,Pardon, E.,Remaut, H.,De Greve, H. The Molecular Mechanism of Shiga Toxin Stx2e Neutralization by a Single-domain Antibody Targeting the Cell Receptor-binding Domain. J.Biol.Chem., 289:25374-25381, 2014 Cited by PubMed: 25053417DOI: 10.1074/jbc.M114.566257 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.818 Å) |
Structure validation
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