4P0V
Crystal structure of human farnesyl diphosphoate synthase in complex with zoledronate and taxodione
Summary for 4P0V
| Entry DOI | 10.2210/pdb4p0v/pdb |
| Descriptor | Farnesyl pyrophosphate synthase, ZOLEDRONIC ACID, (5beta)-11-hydroxyabieta-7,9(11),13-triene-6,12-dione, ... (5 entities in total) |
| Functional Keywords | human, fpps, inhibitor, complex, synthase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 40575.01 |
| Authors | Liu, Y.L.,Oldfield, E. (deposition date: 2014-02-23, release date: 2014-07-02, Last modification date: 2023-12-27) |
| Primary citation | Liu, Y.L.,Lindert, S.,Zhu, W.,Wang, K.,McCammon, J.A.,Oldfield, E. Taxodione and arenarone inhibit farnesyl diphosphate synthase by binding to the isopentenyl diphosphate site. Proc.Natl.Acad.Sci.USA, 111:E2530-E2539, 2014 Cited by PubMed: 24927548DOI: 10.1073/pnas.1409061111 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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