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4ORH

Crystal structure of RNF8 bound to the UBC13/MMS2 heterodimer

Replaces:  4EPO
Summary for 4ORH
Entry DOI10.2210/pdb4orh/pdb
DescriptorUbiquitin-conjugating enzyme E2 variant 2, Ubiquitin-conjugating enzyme E2 N, E3 ubiquitin-protein ligase RNF8, ... (4 entities in total)
Functional Keywordscoiled-coil, e3 ubiquitin ligase, ubiquitin, protein binding-ligase, protein binding-ligase complex, protein binding/ligase
Biological sourceHomo sapiens (human)
More
Cellular locationNucleus : P61088 O76064
Total number of polymer chains11
Total formula weight194211.17
Authors
Campbell, S.J.,Edwards, R.A.,Glover, J.N.M. (deposition date: 2014-02-11, release date: 2014-02-26, Last modification date: 2024-02-28)
Primary citationCampbell, S.J.,Edwards, R.A.,Leung, C.C.,Neculai, D.,Hodge, C.D.,Dhe-Paganon, S.,Glover, J.N.
Molecular insights into the function of RING finger (RNF)-containing proteins hRNF8 and hRNF168 in Ubc13/Mms2-dependent ubiquitylation.
J.Biol.Chem., 287:23900-23910, 2012
Cited by
PubMed: 22589545
DOI: 10.1074/jbc.M112.359653
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (4.802 Å)
Structure validation

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