4ONT

Ternary host recognition complex of complement factor H, C3d, and sialic acid

Summary for 4ONT

• Entry DOI: 10.2210/pdb4ont/pdb
• Descriptor: Complement factor H, Complement C3d fragment, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: complement control protein, ccp, short consensus repeat, scr, sushi domain, complement regulation, sialic acid, host glycan, host cell surface, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P08603 P01024
• Total number of polymer chains: 6
• Total formula weight: 153200.01

Authors

Blaum, B.S.,Stehle, T.S. (deposition date: 2014-01-29, release date: 2014-11-26, Last modification date: 2023-09-20)

• Primary citation: Blaum, B.S.,Hannan, J.P.,Herbert, A.P.,Kavanagh, D.,Uhrin, D.,Stehle, T.; Structural basis for sialic acid-mediated self-recognition by complement factor H.; Nat.Chem.Biol., 11:77-82, 2015; PubMed: 25402769; DOI: 10.1038/nchembio.1696

Experimental method

X-RAY DIFFRACTION (2.15 Å)