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4OGI

Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor BI-2536

Summary for 4OGI
Entry DOI10.2210/pdb4ogi/pdb
Related4OGJ
DescriptorBromodomain-containing protein 4, 1,2-ETHANEDIOL, 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide, ... (4 entities in total)
Functional Keywordsbromodomain, bromodomain containing protein 4, plk1 kinase inhibitor, structural genomics, structural genomics consortium, sgc, transcription-inhibitor complex, transcription/inhibitor
Biological sourceHomo sapiens (human)
Cellular locationNucleus: O60885
Total number of polymer chains2
Total formula weight31366.20
Authors
Primary citationCiceri, P.,Muller, S.,O'Mahony, A.,Fedorov, O.,Filippakopoulos, P.,Hunt, J.P.,Lasater, E.A.,Pallares, G.,Picaud, S.,Wells, C.,Martin, S.,Wodicka, L.M.,Shah, N.P.,Treiber, D.K.,Knapp, S.
Dual kinase-bromodomain inhibitors for rationally designed polypharmacology.
Nat.Chem.Biol., 10:305-312, 2014
Cited by
PubMed: 24584101
DOI: 10.1038/nchembio.1471
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.73 Å)
Structure validation

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