4OGA

Insulin in complex with Site 1 of the human insulin receptor

Summary for 4OGA

• Entry DOI: 10.2210/pdb4oga/pdb
• Related: 3W11 3W12 3W13
• Descriptor: Insulin A chain, Insulin B chain, monoclonal antibody fab 83-7 fragment - heavy chain, ... (9 entities in total)
• Functional Keywords: cell surface receptor/immune system, insulin receptor, ct peptide, insulin, hormone receptor-hormone-immune system complex, hormone receptor/hormone/immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 71687.23

Authors

Lawrence, M.C.,Menting, J.G. (deposition date: 2014-01-15, release date: 2014-08-27, Last modification date: 2023-09-20)

• Primary citation: Menting, J.G.,Yang, Y.,Chan, S.J.,Phillips, N.B.,Smith, B.J.,Whittaker, J.,Wickramasinghe, N.P.,Whittaker, L.J.,Pandyarajan, V.,Wan, Z.L.,Yadav, S.P.,Carroll, J.M.,Strokes, N.,Roberts, C.T.,Ismail-Beigi, F.,Milewski, W.,Steiner, D.F.,Chauhan, V.S.,Ward, C.W.,Weiss, M.A.,Lawrence, M.C.; Protective hinge in insulin opens to enable its receptor engagement.; Proc.Natl.Acad.Sci.USA, 111:E3395-E3404, 2014; PubMed: 25092300; DOI: 10.1073/pnas.1412897111

Experimental method

X-RAY DIFFRACTION (3.5 Å)