5MJ4

INTERLEUKIN-23 COMPLEX WITH AN ANTAGONISTIC ALPHABODY, CRYSTAL FORM 2

Replaces:  4OG9

Summary for 5MJ4

• Entry DOI: 10.2210/pdb5mj4/pdb
• Related: 5MJ3
• Descriptor: Interleukin-12 subunit beta, Interleukin-23 subunit alpha, ALPHABODY MA12, ... (4 entities in total)
• Functional Keywords: single-chain antiparallel triple-helix coiled-coil, immunoglobulin-like, 4-alpha helical bundle, antagonist, n-linked glycosylation, cytokine-antagonist complex, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 67351.65

Authors

Desmet, J.,Verstraete, K.,Bloch, Y.,Lorent, E.,Wen, Y.,Devreese, B.,Vandenbroucke, K.,Loverix, S.,Hettmann, T.,Deroo, S.,Somers, K.,Henderikx, P.,Lasters, I.,Savvides, S. (deposition date: 2016-11-29, release date: 2017-01-11, Last modification date: 2024-01-17)

• Primary citation: Desmet, J.,Verstraete, K.,Bloch, Y.,Lorent, E.,Wen, Y.,Devreese, B.,Vandenbroucke, K.,Loverix, S.,Hettmann, T.,Deroo, S.,Somers, K.,Henderikx, P.,Lasters, I.,Savvides, S.; STRUCTURAL BASIS OF IL-23 ANTAGONISM BY AN ALPHABODY PROTEIN; Nature Communications, 5:5237-, 2014; PubMed: 25354530; DOI: 10.1038/NCOMMS6237

Experimental method

X-RAY DIFFRACTION (3.4 Å)