4OCR

Crystal structure of human Fab CAP256-VRC26.01, a potent V1V2-directed HIV-1 neutralizing antibody

Summary for 4OCR

• Entry DOI: 10.2210/pdb4ocr/pdb
• Related: 4OCS 4OCW 4OD1 4OD3 4ODH 4ORG
• Descriptor: CAP256-VRC26.01 light chain, CAP256-VRC26.01 heavy chain (3 entities in total)
• Functional Keywords: fab, hiv-1, v1v2, cap256, vrc26, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 50384.04

Authors

Gorman, J.,Doria-Rose, N.A.,Schramm, C.A.,Moore, P.L.,Mascola, J.R.,Shapiro, L.,Morris, L.,Kwong, P.D. (deposition date: 2014-01-09, release date: 2014-02-26, Last modification date: 2023-12-06)

• Primary citation: Doria-Rose, N.A.,Schramm, C.A.,Gorman, J.,Moore, P.L.,Bhiman, J.N.,Dekosky, B.J.,Ernandes, M.J.,Georgiev, I.S.,Kim, H.J.,Pancera, M.,Staupe, R.P.,Altae-Tran, H.R.,Bailer, R.T.,Crooks, E.T.,Cupo, A.,Druz, A.,Garrett, N.J.,Hoi, K.H.,Kong, R.,Louder, M.K.,Longo, N.S.,McKee, K.,Nonyane, M.,O'Dell, S.,Roark, R.S.,Rudicell, R.S.,Schmidt, S.D.,Sheward, D.J.,Soto, C.,Wibmer, C.K.,Yang, Y.,Zhang, Z.,Sequencing, Nisc Comparative,Mullikin, J.C.,Binley, J.M.,Sanders, R.W.,Wilson, I.A.,Moore, J.P.,Ward, A.B.,Georgiou, G.,Williamson, C.,Abdool Karim, S.S.,Morris, L.,Kwong, P.D.,Shapiro, L.,Mascola, J.R.; Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies.; Nature, 509:55-62, 2014; PubMed: 24590074; DOI: 10.1038/nature13036

Experimental method

X-RAY DIFFRACTION (1.895 Å)